An April 21, 2013 article in the New York Times describes the budding field of Precision Medicine. The article highlights Weill Cornell’s state-of-the-art Cancer Center and how Precision Medicine is being used to treat patients with Leukemia. To read the full article, click here.
New Clinical Trial: Combination Chemotherapy and Dasatinib in Treating Patients With Newly Diagnosed Acute Myeloid LeukemiaPosted: March 26, 2012
The Weill Cornell Leukemia Program is now recruiting patients for a new study, “CALGB 10801: A Phase II Study of Induction (Daunorubicin/Cytarabine) and Consolidation (High-Dose Cytarabine) Chemotherapy Plus Dasatinib and Continuation Therapy with Dasatinib Alone in Newly Diagnosed Patients with Core Binding Factor Acute Myeloid Leukemia (AML).”
The physician leading the study at Weill Cornell is Gail Roboz, MD. For more information or to see if you are eligible for the study, please contact Tania Curcio, RN at (212) 746-2571 or email Tania at firstname.lastname@example.org.
This is a clinical trial for patients with acute myeloid leukemia (AML) that possesses an abnormal molecular feature (a gene mutation). The purpose of this study is to test the safety and effectiveness of adding the drug dasatinib to a treatment regimen in patients with AML and to determine how well the leukemia responds to the treatment. The study is being done because currently available treatment is not effective in curing patients with this type of leukemia.
There are three parts to the treatment in this study. The first part of the therapy will test the safety and effectiveness of adding dasatinib to the standard combination of chemotherapy drugs used to treat AML that include daunorubicin and cytarabine. The second part of the therapy will test the safety and effectiveness of combining dasatinib with another chemotherapy treatment, consolidation therapy with high-dose cytarabine. Finally, the third part of the therapy will test the effectiveness of the use of dasatinib alone for 12 months during continuation therapy.
Patients will receive therapy for about 18 months on study. After you are finished with the therapy, you will be asked to visit the office for follow-up at least every 2 months for 2 years, then every 3 months for 2 years, then yearly for a maximum of 10 years from when you entered the study.
- Men and women age 18 and older
- Acute myeloid leukemia (AML with Core Binding Factor (CBF) abnormality
- No prior chemotherapy for leukemia or myelodysplasia
- Detailed eligibility reviewed when you contact the study team
Dr. Gail Roboz spoke with ecancertv at ASH 2011 in San Diego about the major genomic research on acute myeloid leukaemia. There has been a lot of recent success on identifying mutations and abnormalities in AML; however, Prof Roboz believes that the discovery period with genomic research is coming to an end and a move towards clinical trials and targeted therapies need to be developed. The largest development has been the role of stems cell in research and how to target the cells that are left over after chemotherapy.
Two Leukemia Program physicians, Dr. Gail Roboz and Dr. Karen Carlson were asked to speak at the 2011 American Society of Hematology (ASH) Annual Meeting in San Diego.
Leukemia Program Director, Dr. Gail Roboz, gave a presentation titled, “Novel Approaches to the Treatment of AML” during the “Acute Myeloid Leukemia in the Age of Genomics” session. Dr. Roboz also contributed to the 2011 Hematology Education Program Book.
Dr. Karen Carlson gave an oral presentation during the session, “Hematopoiesis and Stem Cells- Microenvironment, Cell Adhesion and Stromal Stem Cells: Regulators of the Stem Cell Niche,” and authored an abstract titled “Laminin is Necessary for Maintenance of the Vascular Hematopoietic Niche.”
ASH is the world’s largest professional society concerned with the causes and treatments of blood disorders. For information about ASH, click here.
The work of Drs. Ritchie, Roboz, Scandura, Gergis, and Feldman, and nurse Tania Curcio was presented at the 2009 American Society of Clinical Oncology Annual Meeting. The presentation focused on a clinical trial treating elderly AML and high-grade MDS patients. To view the presentation, click here.
Dr. Gail Roboz contributed to a comprehensive newsletter highlighting developments at the recent 2011 ASCO Annual Meeting.
Dr. Ritchie discusses the treatments available for acute leukemias.